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Nathan Goodyear

Reciprocal Changes in Serum Concentrations of 3,3',5'-Triiodothyronine (Reverse T3) and 3,3'5-Triiodothyronine (T3) in Systemic Illnesses -- CHOPRA et al. 41 (6): 1043 -- Journal of Clinical Endocrinology & Metabolism - 0 views

  • The mechanism or the biological significance of such a diversion of T4, from the normally occurring conversion to highly potent T3, to the generation of poorly calorigenic rT3 in systemic illness
  • such a change in the metabolism of T4 can be reversible.
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    effects of systemic illness on thyroid function: elevated Reverse T3 and low free T3
Nathan Goodyear

Specific 3,3′,5′-Triiodothyronine (Reverse T3) Binding Sites on Rat Liver Plasma Membranes: Comparison with Thyroxine (T4) Binding Sites, Journal of Receptors and Signal Transduction, Informa Healthcare - 0 views

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    rat model finds T4 and rT3 receptors at plasma membrane.  T3 was found to bind with lower affinity than rT3 and T4 at the same receptor binding site.
Nathan Goodyear

Adverse effects of reverse triiodothyronine on cellular metabolism as assessed by 1H and 31P NMR spectroscopy. - ResearchGate - 0 views

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    Only abstract available here.  In vitro study finds that rT3 decreased the metabolic effect of T3.  This gives the impression that rT3 has an antagonist effect to T3 on the receptor.
Nathan Goodyear

A Radioimmunoassay for 3,3',5'-L-Triiodothyronine (Reverse T3): Assessment of Thyroid Gland Content and Serum Measurements in Conditions of Normal and Altered Thyroidal Economy and Following Administration of Thyrotropin Releasing Hormone (TRH) and Thyrot - 0 views

  • Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis.
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    oral estrogen supplementation increase reverse T3 and lowers metabolism and leads to weight gain
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